Abstract P5-16-14: Outcome of lipofilling in patients with a history of breast cancer: A retrospective cohort study

Background:Autologous fat grafting [AFG] is a surgical technique used to correct breast deformities or to reconstruct partial breast deformities after breast conservative treatment [BCT] or mastectomy for breast cancer. However, a strong debate remains upon the topic of safety and the oncological risk after lipofilling. There is a need for more studies assigned with a higher level of evidence. Objective:This retrospective cohort study aimed to provide a strong evidence-based argument concerning the safety of fat grafting in patients who underwent breast cancer surgery in comparison to a group with similar characteristics who did not receive lipofilling. Methods: Two cohorts consisting of women with a history of breast cancer were retrospectively assembled. All patients underwent BCT and/or a mastectomy as breast cancer treatment. An intervention population of patients that had received primary or secondary lipofilling was statistically compared to a control population of patients that had received a breast reconstruction without lipofilling. Results: Fifty patients with a mean age of 53.6 ± 9.3 years at the time of lipofilling were included in the intervention cohort. The control group included 67 patients with a mean age of 52.8 ± 8.5 years at the time of breast reconstruction. Both cohorts showed no significant differences for demographic or oncological data. Mean follow-up time was 15.0 ± 15.6 months in the intervention group and 45.4 ± 35.1 months in the control group. The prevalence of the complications are shown in the table. No complications were seen in 35 patients [70%] after lipofilling. Fat necrosis was mostly observed [n=15] but no infections or local oncological recurrences were reported. In the control group a complication-free follow-up occurred in 38 patients [56.7%] after breast reconstruction. One control patient demonstrated a local oncological recurrence. A higher prevalence of infections was observed in the control population [p = 0.048] and the prevalence of fat necrosis was higher after lipofilling [p = 0.028]. Conclusion: Lipofilling is a safe technique for breast reconstruction in patients with a history of breast cancer. There is no increase in local oncological recurrence. A side effect is an increase in fat necrosis which can potentially lead to more investigations. Citation Format: Thiessen F, De Schrijver L, De Decker M, Tondu T, Van Goethem M, Tjalma WA. Outcome of lipofilling in patients with a history of breast cancer: A retrospective cohort study [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P5-16-14.