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The Roles of Chemokine (C-X-C motif) Ligand 13 in Spinal Cord Ischemia-Reperfusion Injury in Rats.

Fengshou Chen,Xiaoqian Li,Zhe Li,Yongjian Zhou,Ziyun Qiang,Hong Ma

Brain Research（2020）

Cited 16|Views14
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Abstract
•Spinal cord ischemia-reperfusion injury (SCII) increased the expression of CXCL13.•CXCL13 protein was co-expressed with the NeuN and IBA-1 in SCII in rats.•SCII increased the expression of CXCR5, p-ERK, caspase-3, IL-6, TNF-α, IL-1β.•Silencing CXCL13 or CXCR5 protected against SCII, decreased ERK-mediated pathways.
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Key words
Spinal cord ischemia-reperfusion injury,C-X-C motif ligand 13,C-X-C chemokine receptor type 5,Extracellular signal-regulated kinase
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