Fixed Dosing of Liposomal Amphotericin B in Morbidly Obese Individuals

Roeland E. Wasmann, Cornelis Smit, Eric P. H. van Dongen, Rene M. J. Wiezer, Jill Adler-Moore, Yvo M. de Beer, David M. Burger, Catherijne A. J. Knibbe,Roger J. M. Bruggemann

CLINICAL INFECTIOUS DISEASES（2020）

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摘要

In this prospective study, we examined the pharmacokinetics of 1 and 2 mg/kg liposomal amphotericin B in 16 morbidly obese individuals (104-177 kg). Body size had no effect on clearance. We recommend a fixed dose in patients >= 100 kg (ie, 300 or 500 mg rather than the current dose of 3 and 5 mg/kg, respectively).

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关键词

fungal treatment,fungal infection,obese,population pharmacokinetics,optimal dosing

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