Apelin-36 Mediates Neuroprotective Effects by Regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson's Disease model mice.

•Apelin-36 protected against MPTP-induced dopamine depletion in the STR of mice.•Apelin-36 reduced oxidative stress and iNOS expression in MPTP-treated mice.•Apelin-36 reversed MPTP-induced nitrated α-synuclein expression in mice.•Apelin-36 alleviated the impaired autophagy induced by MPTP of mice.•Apelin-36 inhibited ASK1/JNK/caspase-3 apoptotic pathway in mice.