Apelin-36 Mediates Neuroprotective Effects by Regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson's Disease model mice.
Brain Research(2020)
Abstract
•Apelin-36 protected against MPTP-induced dopamine depletion in the STR of mice.•Apelin-36 reduced oxidative stress and iNOS expression in MPTP-treated mice.•Apelin-36 reversed MPTP-induced nitrated α-synuclein expression in mice.•Apelin-36 alleviated the impaired autophagy induced by MPTP of mice.•Apelin-36 inhibited ASK1/JNK/caspase-3 apoptotic pathway in mice.
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Key words
Parkinson’s disease,Apelin-36,1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin,Nitrated α-synuclein,Oxidative stress,Autophagy
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