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The neuroprotective effects of novel estrogen receptor GPER1 in mouse retinal ganglion cell degeneration.

Meng-Nan Jiang,Xue-Yun Ma,Qing-Qing Zhao,Ying Li,Yi-Qiao Xing,Qin-Qin Deng,Yin Shen

Experimental Eye Research（2019）

Cited 16|Views6
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Abstract
•The novel estrogen receptor GPER1 expressed in the inner retina.•Activation of GPER1 showed protective effects of RGCs in NMDA induced injury.•PI3K/Akt pathway was involved in the regulatory network of GPER1.•GPER1 activation also showed protective effects in acute ocular hypertension.
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Key words
17-β-estradiol,GPER1,RGCs,NMDA,Apoptosis
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