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Single-cell transcriptomics reveal polyclonal memory T-cell responses in skin with positive abacavir patch test results.

Alec James Redwood,Francois Rwandamuriye,Abha Chopra,Shay Leary,Ramesh Ram,Wyatt McDonnell,Katherine Konvinse,Katie White,Rebecca Pavlos,David M Koelle,Simon Mallal,Elizabeth J Phillips

The Journal of allergy and clinical immunology（2019）

Cited 18|Views61
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Abstract
Single-cell responses in HLA-B*57:01 abacavir patch test positive skin remote to the acute hypersensitivity reaction demonstrate polyclonal T-cell activation and proliferation characterized by a transcriptional and cellular response consistent with memory responses to altered peptides.
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