Pharmacokinetic comparative study of tetramethylpyrazine and ferulic acid and their compatibility with different concentration of gastrodin and gastrodigenin on blood-stasis migraine model by blood-brain microdialysis method.

•Cold stimulate vasoconstriction which was based on the migraine model, because of that, a dual model was created.•The pharmacokinetic effects containing Gastrodin and Gastrodigenin on TMP and FA of Ligusticum chuanxiong was studied..•The PK of active constituents of traditional Chinese medicine was studied by blood-brain microdialysis method.