Therapy for myocardial infarction: In vitro and in vivo evaluation of puerarin-prodrug and tanshinone co-loaded lipid nanoparticulate system.

•Myocardial infarction is the leading cause of morbidity and mortality worldwide.•A nanoparticle system was developed to treat myocardial infarction.•PUE-prodrug contained, double drugs co-loaded SLN was produced.•It could be utilized as promising candidate myocardial infarction therapy.