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Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.

N Tarazona,F Gimeno-Valiente,V Gambardella,S Zuñiga,P Rentero-Garrido,M Huerta,S Roselló,C Martinez-Ciarpaglini,J A Carbonell-Asins, F Carrasco,A Ferrer-Martínez,G Bruixola,T Fleitas, J Martín,R Tébar-Martínez,D Moro,J Castillo,A Espí,D Roda,A Cervantes

Annals of oncology : official journal of the European Society for Medical Oncology（2019）

Cited 150|Views33
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Abstract
Plasma postoperative ctDNA detected MRD and identified patients at high risk of relapse in localized CC. Mutation tracking with more than one variant in serial plasma samples improved our accuracy in predicting MRD.
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Key words
colon cancer,droplet digital PCR,minimal residual disease,next-generation sequencing,plasma circulating-tumor DNA
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