Effect of diversity in gp41 membrane proximal external region of primary HIV-1 Indian subtype C sequences on interaction with broadly neutralizing antibodies 4E10 and 10E8.

Jyoti Sutar,Varsha Padwal,Archana Sonawani,Vidya Nagar,Priya Patil, Bhalachandra Kulkarni,Nitin Hingankar,Suprit Deshpande,Susan Idicula-Thomas,Dhanashree Jagtap,Jayanta Bhattacharya,Atmaram Bandivdekar,Vainav Patel

Virus Research（2019）

Cited 5|Views15

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Abstract

•Diversity characterization of MPER bNAb epitopes from HIV-1 clade C within India.•Identification of primary, uncultured circulating variants through meta-analysis and NGS.•Haplotype based in silico screening of epitope-bNAB interactions for 10E8 and 4E10.•In vitro validation for heretofore untested (for neutralization) epitopes from India.•Need of regular epitope diversity surveillance for development of efficacious bNAb based interventions.

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Key words

HIV-1 clade C,MPER,India,Deep sequencing,Broadly neutralizing antibodies,10E8

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