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Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019.

David J Roberts,Grahame S Davis,Michelle J Cole, Dixita Naik, Hitiksha Maru,Neil Woodford,Peter Muir,Paddy Horner,Ian Simms, George Thickett,Paul Crook,Kirsty Foster,Nick Andrews,John Saunders,Helen Fifer,Kate Folkard,O Noel Gill, On Behalf Of The Incident Management Team

EUROSURVEILLANCE（2019）

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Abstract
We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.
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Key words
Chlamydia trachomatis,epidemiology,nucleic acid amplification testing
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