Comparison of risk factors for postoperative complications across age groups in patients undergoing ORIF of the ankle.

•Age is significantly associated with incidence of nonunion.•Risk of infection is significantly increased in patients younger than 50 with CKD and in all patients with CHF and HTN.•Risk of wound dehiscence is significantly associated with tobacco use, substance use, and CHF in younger patients.•Risk of implant failure is significantly increased in younger patients with HIV, CHF, and CKD, and older patients with HTN.•A multidisciplinary approach is warranted for appropriate management of patients with multiple comorbidities.