Rational discovery of a highly novel and selective mTOR inhibitor.

Stanley Jin,Satoshi Mikami,Nick Scorah,Young Chen,Petro Halkowycz,Lihong Shi,Jason Kahana,Patrick Vincent,Ron de Jong,Joy Atienza,Robyn Fabrey,Lilly Zhang, Matthew Lardy

Bioorganic & medicinal chemistry letters（2019）

引用 6|浏览16

暂无评分

摘要

Aided by Structure Based Drug Discovery (SBDD), we rapidly designed a highly novel and selective series of mTOR inhibitors. This chemotype conveys exquisite kinase selectivity, excellent in vitro and in vivo potencies and ADME safety profiles. These compounds could serve as good tools to explore the potential of TORC inhibition in various human diseases.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要