An in silico study examining the role of airway smooth muscle dynamics and airway compliance on the rate of airway re-narrowing after deep inspiration.

•Deep inspirations (DIs) are important because of their ability to dilate airways in asthma.•Previous work suggests that the interval between Dis affect only rate of airway smooth muscle force recovery but had no effect on measured bronchodilatory effect.•We show that this can be adequately explained via airway smooth muscle crossbridge dynamics, coupled with non-linear airway wall compliance.