Effects of hypoxia inducible factor-1α on expression levels of MLCK, p-MLC and ZO-1 of rat endothelial cells.

•A large number of transcription factors are involved in various responses of cells and organisms under hypoxic conditions.•Hypoxia inducible factor-1 is considered to be the most important transcription factor that mediates hypoxic response of body.•HIF-1α positively regulates the expression of MLCK and p-MLC and negatively regulates the expression of ZO-1 in rat monolayer endothelial cells. .