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A new bile acid from the traditional chinese medicine shedan

Yan Yuan,Qiu-Yan Wang,Jie Zhang,Jing Nie,Cheng-Gao Zhou, Wen-Qin Yi,Luo-Sheng Wan,Jia-Chun Chen

Journal of Asian Natural Products Research（2020）

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Abstract
A new bile acid tauro-16β-hydroxy-12α-sulfate-5β-cholenoic acid (1), along with six known ones (2–7), was isolated from the snake bile. Its planar structure and relative configuration were elucidated based on extensive spectroscopic analyses. Moreover, compound 2 showed inhibitory effect on NO production in RAW 264.7 macrophages at non-cytotoxic concentration (20 μM) with inhibitory rate of 69.7%.
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Key words
Snake bile,bile acids,anti-inflammatory effect,bioactive substances basis
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