Relationship Between Hereditary Cancer Syndromes and Oncotype DX Recurrence Score.

Nicole Casasanta, Sarit T Kipnis,Laura Linville, Shawn Lipinski, Alice Knoedler, Amy Marino, Allision McHenry,Tara Biagi,Elizabeth Stark,Richard Amdur,Neelima Denduluri,Patricia Rodriguez,Claudine Isaacs,Rebecca Kaltman

Clinical Breast Cancer（2020）

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摘要

High RS is associated with germline mutation status. Breast cancer patients with high RS are more likely to harbor a mutation in the BRCA1 or BRCA2 genes. If confirmed prospectively, oncologists may consider referring patients with high RS for genetic risk assessment and counseling to inform management plans, as well as counseling of family members.

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关键词

BRCA1,BRCA2,21-Gene recurrence score assay,Genetic risk assessment,Hereditary breast cancer

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