Dissecting the mechanisms of bone loss in Gorham-Stout disease.

Michela Rossi,Paola Sabrina Buonuomo,Giulia Battafarano,Antonella Conforti, Eda Mariani,Mattia Algeri,Simone Pelle, Matteo D'Agostini,Marina Macchiaiolo,Rita De Vito,Michaela Veronika Gonfiantini,Alessandro Jenkner,Ippolita Rana,Andrea Bartuli,Andrea Del Fattore

Bone（2020）

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摘要

•Bone biopsy analysis of Gorham-Stout patients revealed increased vessels, osteoclast number and osteocyte lacunar area.•In vitro experiments displayed increased osteoclast differentiation/activity and reduced osteoblast function.•Patients’ sera stimulated osteoclastogenesis, bone resorption and reduced mineralization of control cells.•The treatment of endothelial cell line EA.hy926 with patients’ sera enhanced vessel formation.

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关键词

Gorham-Stout disease,Osteolysis,Osteoclast,Bone histomorphometry,Osteoblast

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