Anti-atherosclerotic effects of an improved apolipoprotein A-I mimetic peptide.

•Apolipoprotein (Apo)A-I is a major protein component of high-density lipoprotein.•We newly developed an improved Fukuoka University ApoA-I Mimetic Peptide (i-FAMP-D1).•i-FAMP-D1 formed stronger α-helical conformations and had a superior atheroprotective effect in ApoE knockout mice.•i-FAMP-D1 activated cholesterol efflux from macrophage to HDL and increased cholesterol excretion from liver to feces.