Dysregulation of the miR-325-3p/DPAGT1 axis supports HBV-positive HCC chemoresistance.
Biochemical and Biophysical Research Communications（2019）
Abstract
•DPAGT1 is upregulated in DOX-resistant HBV + HCC cell lines.•Enhancing DPAGT1 activity improves DOX-resistant cell survival.•DPAGT1 silencing or inhibition inhibits xenograft tumor growth under DOX treatment.•miR-325–3p negatively modulates DPAGT1 expression and reverses its effects.•High DPAGT1 and low miR-325–3p are associated with a poor chemotherapeutic response.
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Key words
HCC,Liver cancer,Chemoresistance,Doxorubicin,miR-325,DPAGT1
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