Mechanism of stimulation of DNA binding of the transcription factors by human apurinic/apyrimidinic endonuclease 1, APE1.

Milena Bazlekowa-Karaban,Paulina Prorok,Sonia Baconnais,Sabira Taipakova,Zhiger Akishev,Dominika Zembrzuska,Alexander V Popov,Anton V Endutkin,Regina Groisman,Alexander A Ishchenko,Bakhyt T Matkarimov,Amangeldy Bissenbaev,Eric Le Cam,Dmitry O Zharkov,Barbara Tudek,Murat Saparbaev

DNA Repair（2019）

引用 26|浏览16

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摘要

•APE1 forms a stable complex with ssDNA longer than 15 mer;•APE1-catalyzed repair and TF-stimulating activities depend on the structure of DNA duplex;•APE1 acts synergistically with reducing agents to stimulate DNA binding of AP-1 and p50;•APE1 stimulates DNA binding of p50-C62S redox-insensitive mutant;•APE1 forms stable multiprotein oligomers on intrinsically curved DNA regions.

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关键词

ROS,AP,THF,αdA,Z,BER,NIR,APE1,Nfo,ARP,wARP

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