miR-221-5p acts as an oncogene and predicts worse survival in patients of renal cell cancer.
Biomedicine & Pharmacotherapy(2019)
摘要
•MiR-221-5p is significantly up-regulated in RCC tissues and RCC cell lines.•MiR-221-5p promotes cell proliferation, mobility and inhibits cell apoptosis in 786-O and ACHN cell lines.•The Kaplan-Meier analysis indicated that patients with high expression of miR-221-5p had a significantly poor prognosis.•The Cox regression analyses showed that patients with high expression of miR-221-5p remained to have a shorter overall survival.•MiR-221-5p may not only be an oncogene in RCC cells but also might be an independent prognosis factor of RCC.
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关键词
MicroRNAs,miR-221-5p,Renal cell cancer,Prognosis biomarkers
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