Synthesis And Antimicrobial Studies Of 4-[3-(3-Fluorophenyl)-4-Formyl-1h-Pyrazol-1-Yl]Benzoic Acid And 4-[3-(4-Fluorophenyl)-4-Formyl-1h-Pyrazol-1-Yl]Benzoic Acid As Potent Growth Inhibitors Of Drug-Resistant Bacteria

Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 mu g/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.