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Mitophagy mediated by BNIP3 and BNIP3L/NIX in urothelial cells of the urinary bladder of cattle harbouring bovine papillomavirus infection.

Sante Roperto,Francesca De Falco,Antonella Perillo,Cornel Catoi,Franco Roperto

Veterinary Microbiology（2019）

Cited 22|Views26
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Abstract
•BNIP3- and BNIP3L/NIX-mediated mitophagy occurs in hypoxic cells infected by BPVs.•LC3, p62, ERAS and Bag3 are interactors of BNIP3 and BNIP3L/NIX.•BPV E5 oncoprotein is detected with ERAS at mitochondrial level.•Mitochondrial abnormalities are ultrastructural features of cells infected by BPVs.•Urothelial cells infected by BPVs contain numerous mitophagosomes.
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BPV E5 oncoprotein,BNIP3,BNIP3L/Nix,Mitophagy receptors,Bag3,HIF-1α
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