Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis.

Dongqin Yang,Qi Zhang,Yunfang Ma,Zhihui Che,Wenli Zhang,Mengmeng Wu,Lijun Wu,Fuchen Liu,Yiwei Chu,Wei Xu,Mary McGrath,Chunhua Song,Jie Liu

EBioMedicine（2019）

Cited 26|Views14

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Abstract

Our data confirmed the therapeutic effect of adenosine on pancreatic cancer, and revealed the potential of Akt inhibitors as sensitization agents in this treatment. FUND: The work is supported by grants from the National Natural Science Foundation of China to Dongqin Yang (81572336, 81770579) and Jie Liu (81630016, 81830080), and jointly by the Development Fund for Shanghai Talents (201660).

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Key words

Adenosine,Akt-p21 axis,Pancreatic cancer,GSK690693

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