miR-138 activates NF-κB signaling and PGRN to promote rheumatoid arthritis via regulating HDAC4.

Biochemical and Biophysical Research Communications（2019）

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摘要

•miR-138 promotes expression of inflammatory cytokines.•HDAC4 knockdown rescues miR-138-regulated expression of inflammatory cytokines.•NF-κB signaling is crucial for miR-138-regulated inflammatory cytokines expression.•PGRN rescues miR-138-regulated inflammatory cytokines expression.

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关键词

Rheumatoid arthritis,miR-138,HDAC4,NF-κB,PGRN,Inflammatory cytokines

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