Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase.

Sivareddy Kotla,Nhat-Tu Le,Hang Thi Vu,Kyung Ae Ko,Young Jin Gi,Tamlyn N Thomas,Carolyn Giancursio, Aldos J Lusis,John P Cooke,Keigi Fujiwara,Jun-Ichi Abe

Metabolism（2019）

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摘要

•Disturbed flow induces senescence-associated secretory phenotype via TERF2IP.•TERF2IP S205 phosphorylation is crucial for regulating EC senescence and activation.•TERF2IP provokes trans-repression of the distinct reciprocal gene set.•MKRN1 is a key molecule for the inhibition of TERF2IP-dependent SASP.

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关键词

ANOVA,d-flow,EC,EKO,FITC,HAECs,HUVEC,MKRN1,miRNA,p90RSK,PBS,PCR,RICTOR,SASP,TERF2,TERF2IP,TERT,WT

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