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Applying vinpocetine to reverse synaptic ultrastructure by regulating BDNF-related PSD-95 in alleviating schizophrenia-like deficits in rat.

Yue Xu,Chao Deng,Yongqiang Zheng,Nannuan Liu,Beibei Fu

Comprehensive Psychiatry（2019）

Cited 20|Views10
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Abstract
•BDNF-related PSD-95 might be involved in schizophrenia-like deficits.•Synaptic ultrastructure parameters were changed in rat model of schizophrenia.•Vinpocetine could reverse ketamine-induced schizophrenia-like deficits in rats.•Vinpocetine may reverse synaptic ultrastructure by regulating BDNF-related PSD-95.
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Key words
Schizophrenia,Vinpocetine,BDNF,PSD-95,Synaptic ultrastructure
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