Association of Complement and Inflammatory Biomarkers with Diabetic Nephropathy.
ANNALS OF CLINICAL AND LABORATORY SCIENCE(2019)
摘要
Objective. To investigate the association between complement and inflammatory biomarkers with diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). Methods. Plasma and urinary complement and inflammatory biomarkers were measured in 115 T2DM patients assigned to one of two groups: with DN (n=48) and without DN (n=67). Results. The plasma and urinary levels of C3a, C4d, C5a, sC5b-9 and MBL (mannan-binding lectin) were significantly higher in T2DM patients with DN compared to T2DM patients without DN. The plasma levels of IL-10 and INF-gamma, as well as the urinary levels of INF-gamma and TNF-alpha in T2DM patients with DN, were significantly higher than T2DM patients without DN. Both urinary MBL and INF-gamma were independent risk factors for DN within T2DM patients (OR, 2.35 (95% CI 2.28-2.64) and 1.17 (95% CI 1.15-1.18); P=0.000 and 0.016, respectively). The area under the receiver-operating-characteristic-curve for urinary MBL was 0.89, with sensitivity 91% and specificity 83% for DN. The area under the receiver-operating-characteristic-curve for INF-gamma was 0.84, with sensitivity 86% and specificity 79% based on cutoff values of 1.42 ng/mg and 5.15 pg/mg, respectively. Conclusion. This study suggests that urinary INF-gamma and MBL levels are independent risk factors with a high predictive power for DN in T2DM patients.
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关键词
Complement activation,Type 2 diabetes mellitus,Diabetic nephropathy,Inflammatory cytokine,Risk factor
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