Protective efficacy in farmed ducks of a duck enteritis virus-vectored vaccine against H5N1, H5N6, and H5N8 avian influenza viruses.

Pucheng Chen,Leilei Ding,Yongping Jiang,Xianying Zeng,Guohua Deng,Jianzhong Shi,Yanbing Li,Liling Liu,Yuhui Zhao,Yuzhen Hu,Jinxiong Liu,Hualan Chen

Vaccine（2019）

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摘要

•Ducks play a key role in the maintenance and spread of avian influenza viruses.•A bivalent vaccine (rDEVus78HA) protect ducks against lethal challenge with DEV and H5N1 virus in a 60-week clinical trial.•rDEVus78HA induce broader protection against heterologous and antigenically drifted H5 influenza viruses.

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关键词

Duck enteritis virus-vectored vaccine,H5 avian influenza viruses,Farmed ducks,Clinical trial

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