Tiny Dancer: EFCAB9 Triggers Sperm Hyperactivation via CatSper.
Trends in Biochemical Sciences（2019）
摘要
The Ca-conducting ion channel, CatSper, is expressed exclusively on the sperm flagellum and regulates sperm motility. A new study (Hwang et al., Cell, 2019) reveals that the pH-sensing and Ca-binding protein, EFCAB9, is a subunit of the CatSper channel and has a key role in triggering mammalian sperm to change their swimming at fertilization.
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