A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice
CELL RESEARCH(2019)
摘要
The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI). However, the calcium channels responsible for this process have remained unknown. Here, we show that rice CDS1 ( CELL DEATH and SUSCEPTIBLE to BLAST 1 ) encoding OsCNGC9, a cyclic nucleotide-gated channel protein, positively regulates the resistance to rice blast disease. We show that OsCNGC9 mediates PAMP-induced Ca 2+ influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression. We further show that a PTI-related receptor-like cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity. Our results suggest a signaling cascade linking pattern recognition to calcium channel activation, which is required for initiation of PTI and disease resistance in rice.
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关键词
Plant immunity,Plant molecular biology,Plant signalling,Life Sciences,general,Cell Biology
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