A fluorogenic H2S-triggered prodrug based on thiolysis of the NBD amine.

Yonghui Xie,Haojie Huang,Ismail Ismail,Hongyan Sun,Long Yi,Zhen Xi

Bioorganic & medicinal chemistry letters（2019）

引用 5|浏览14

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摘要

Based on thiolysis of the NBD amine, a H2S-triggered prodrug has been designed and synthesized for localized production of ciprofloxacin under micromolar H2S. Activation of the prodrug can be monitored through fluorescence in real-time. We envision that thiolysis of the NBD amine could be readily used for development of other H2S-triggered prodrugs in the future.

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