Highly Linear Amperometric Glucose Detection System Realized in Deep Submicron CMOS Technology

The aim of this work is to realize a needle implantable biosensor for continuous monitoring of interstitial glucose levels. A highly miniaturized application specific integrated circuit (ASIC) is designed using 130 nm standard CMOS technology and combined with a glucose biosensor to produce a frequency signal proportional to the glucose concentration level. A prototype system incorporating an on-chip amperometric potentiostat and a signal processing unit (SPU) is designed and implemented to amperiometrically assess the performance of the biosensor in term of measurement of glucose values. This prototype system demonstrated measurement of a wide current range from 1 nA to 10 μA with the output read-out exhibiting linearity higher than 99%. The realized system is optimized with small physical footprint occupying a 1.5 mm × 0.439 mm die and maximum power consumption of about 80 μW.