Up-regulation of hepatic fatty acid transporters and inhibition/down-regulation of hepatic OCTN2 contribute to olanzapine-induced liver steatosis.

•Olanzapine up-regulates hepatic FABP1 and FATP2 expression in livers of female mice.•Olanzapine down-regulates OCTN2 expression in livers of male mice.•Olanzapine inhibits hepatic OCTN2 activity and decreases hepatic L-carnitine level.•L-carnitine supplementation attenuates olanzapine-induced simple steatosis.