Determination of four omega-3 polyunsaturated fatty acids by UPLC-MS/MS in plasma of hyperlipidemic and normolipidemic subjects.

Beibei Zhou,Chao Lin,Saili Xie,Xingxing Zhou,Fan Zhang,Xuemei Ye,Feiyan Lin,Lufeng Hu,Aifang Huang

Journal of Chromatography B（2019）

Cited 6|Views4

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Abstract

•A rapid and sensitive UPLC-MS/MS method for simultaneously determination of ALA, EPA, DHA and DPA has been established.•The validated UPLC-MS/MS method was applied successfully in plasma of hyperlipidemic and healthy subjects.•In hyperlipidemic and healthy subjects, levels of ALA were highest, followed by DHA, EPA and DPA.•There were high degrees of correlation between ALA, EPA, DHA and DPA.

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Key words

Polyunsaturated fatty acids,Human,UPLC-MS/MS,Determination,Plasma

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