Urokinase-type plasminogen activator contributes to amiloride-sensitive sodium retention in nephrotic range glomerular proteinuria in mice.

Gitte R Hinrichs,Kathrin Weyer,Ulla G Friis,Per Svenningsen,Ida Katrine Lund,Rikke Nielsen,Géraldine Mollet,Corinne Antignac,Claus Bistrup,Boye L Jensen,Henrik Birn

Acta physiologica (Oxford, England)（2019）

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摘要

Nephrotic range glomerular proteinuria leads to urokinase dependent intratubular plasminogen activation and γENaC cleavage which contributes to sodium accumulation. This article is protected by copyright. All rights reserved.

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关键词

Collecting duct,ENaC,edema,nephrotic syndrome,podocin,proteases

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