Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates.

Andrew S Fox,Tade Souaiaia,Jonathan A Oler,Rothem Kovner,Jae Mun Hugo Kim,Joseph Nguyen,Delores A French,Marissa K Riedel,Eva M Fekete, Matthew R Rabska,Miles E Olsen,Ethan K Brodsky,Andrew L Alexander,Walter F Block,Patrick H Roseboom,James A Knowles,Ned H Kalin

Biological Psychiatry（2019）

引用 27|浏览49

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摘要

Together, these data implicate neurotrophin-3/NTRK3 signaling in the dorsal amygdala in mediating primate anxiety. More generally, this approach provides an important step toward understanding the molecular underpinnings of early-life AT and will be useful in guiding the development of treatments to prevent the development of stress-related psychopathology.

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关键词

AAV,Amygdala,Anxiety,Anxious temperament,Behavioral inhibition,Central nucleus of the amygdala,Extended amygdala,FDG-PET,Neurotrophic,NTF3,NTRK3,Primate,RNA-seq

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