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Overexpression of CSN6 promotes the epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma.

Ming Xu, Lonbo Zhen, Liumei Lin,Ke Wu, Yifan Wang,Xiujun Cai

Clinics and Research in Hepatology and Gastroenterology（2020）

Cited 7|Views12
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Abstract
•Upregulation of CSN6 expression was significantly associated with the progression and poor survival in HCC patients.•CSN6 promotes proliferation, invasion and migration of HCC cells.•CSN6 led to the metastasis and EMT activation through MEK/ERK pathway.
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Key words
CSN6,Hepatocellular carcinoma,Prognosis,Epithelial-mesenchymal transition
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