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Arsenic trioxide inhibits angiogenesis in vitro and in vivo by upregulating FoxO3a.

Zhuo Sun,Mingyan Li,Lu Bai, Jiaju Fu,Jinqi Lu,Muyu Wu, Chen Zhou,Ying Zhang,Yongping Wu

Toxicology Letters（2019）

Cited 13|Views10
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Abstract
•As2O3 inhibits angiogenesis in vitro and in vivo.•As2O3 upregulates FoxO3a by facilitating its nuclear translocation and inhibiting its protein degradation.•The angiogenesis effect of As2O3 is mediated by upregulation of FoxO3a.
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Key words
Arsenic trioxide,FoxO3a,Angiogenesis
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