Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion.

Peng Wang,Yijun Lu,Donghe Han,Pan Wang,Lili Ren,Jing Bi,Jia Liang

Brain Research（2019）

引用 13|浏览8

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摘要

•The expression of NMNAT1 is increased in the peri-infarct penumbra of aged rats.•Overexpression of NMNAT1 is neuroprotective in aged ischemic rats.•Induction of autophagy contributes to the neuroprotection of NMNAT1.•NMNAT1 regulates neuronal autophagy through SIRT1/mTOR pathway.

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关键词

NMNAT1,MCAO,mTOR,SIRT1,3-MA,OGD,NAD+,TTC,LC3,MTT

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