Optimization of peptide-plasmid DNA vectors formulation for gene delivery in cancer therapy exploring design of experiments.

Ângela Sousa,Ana M Almeida,Rúben Faria,Karidia Konate,Prisca Boisguerin,João A Queiroz,Diana Costa

Colloids and Surfaces B: Biointerfaces（2019）

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摘要

•The pDNA condensation ability of RALA and WRAP5 has been evaluated.•A design of experiments tool (DoE) was used to find the optimal formulations.•The buffer pH and N/P ratio were considered the DoE inputs.•Vector size, zeta potential and pDNA complexation capacity were DoE outputs.•The ideal vectors were revealed: a great contribution for progresses in cancer therapy.

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关键词

peptide/pDNA vectors,pDNA condensation,Design of experiments,Optimal peptide/pDNA formulations,Gene delivery,Cancer gene therapy

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