Immortal Time Bias in National Cancer Data Base Studies.
International Journal of Radiation Oncology*Biology*Physics(2020)
Abstract
Studies assessing adjuvant radiation therapy by analyzing the NCDB are susceptible to ITB, which overestimates the effect size of adjuvant therapies and can provide misleading results. Adjusting for this bias is essential for accurate data representation and to better quantify the impact of adjuvant therapies such as PORT.
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Key words
Immortal Time Bias,Landmark analysis,National Cancer Data Base,Time Dependent
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