Low-dose perampanel improves refractory cortical myoclonus by the dispersed and suppressed paroxysmal depolarization shifts in the sensorimotor cortex.

Kazuki Oi,Shuichiro Neshige,Takefumi Hitomi,Katsuya Kobayashi,Maya Tojima,Masao Matsuhashi,Akihiro Shimotake,Daiki Fujii,Riki Matsumoto,Shuhei Kasama,Masutaro Kanda,Yoshiaki Wada,Hirofumi Maruyama,Ryosuke Takahashi,Akio Ikeda

Clinical Neurophysiology（2019）

引用 36|浏览17

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摘要

•Low dose of perampanel (PER) is tolerable and effective to ameliorate refractory cortical myoclonus.•PER suppresses and disperses paroxysmal depolarization shifts directly on the postsynaptic neurons.•This action was reflected by temporal dispersion in giant SEPs (a potential clinical biomarker).

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关键词

Progressive myoclonus epilepsy,Somatosensory-evoked potential,Primary motor area,Paroxysmal depolarization shift,Excitatory postsynaptic potential

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