Discrepancies in susceptibility testing to colistin in Acinetobacter baumannii: The influence of slow growth and heteroresistance

International Journal of Antimicrobial Agents(2019)

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摘要
•The increasing use of colistin has led to an increase in Acinetobacter baumannii resistance.•This situation has shown limitations of colistin for in vitro susceptibility testing.•The impact of colistin-resistance mechanisms in susceptibility methods was evaluated.•Most of the errors were found in isolates with MIC values close to the breakpoint.•The rapid colistin colorimetric Acinetobacter method showed the best performance.
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关键词
Acinetobacter baumannii,Colistin resistance,Susceptibility testing,Rapid diagnostic test,pmrB gene,lpx gene
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