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New classes of carbazoles as potential multi-functional anti-Alzheimer's agents.

Niloufar Choubdar,Mostafa Golshani,Leili Jalili-Baleh,Hamid Nadri,Tuba Tüylü Küçükkilinç,Beyza Ayazgök,Alireza Moradi,Farshad Homayouni Moghadam,Zahra Abdolahi,Alieh Ameri,Fatemeh Salehian,Alireza Foroumadi,Mehdi Khoobi

Bioorganic Chemistry（2019）

Cited 18|Views5
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Abstract
•Novel carbazoles were introduced as multifunctional anti-Alzheimer’s disease.•Compound 3s having quinolinium part showed high AChE and BuChE inhibition activity.•Compound 3s showed significant anti-Aβ aggregation activity.•Compound 3s exhibited high neuroprotective activity.
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Key words
Alzheimer's disease,Acetylcholinesterase,Butyrylcholinesterase,Carbazoles,Docking study,β-amyloid aggregation
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