Right Ventricular Oxygen Delivery as a Determinant of Right Ventricular Functional Reserve during Exercise in Juvenile Swine with Chronic Pulmonary Hypertension.

Assessing right ventricular (RV) functional reserve is important for determining clinical status and prognosis in patients with pulmonary hypertension (PH). In this study, we aimed to establish RV oxygen (O-2) delivery as a determinant for RV functional reserve during exercise in swine with chronic PH. Chronic PH was induced by pulmonary vein banding (PVB), with sham operation serving as control. RV function and RV O-2 delivery were measured over time in chronically instrumented swine, up to 12 wk after PVB at rest and during exercise. At rest. RV afterload (pulmonary artery pressure and arterial elastance) and contractility (E-es and dP/dt(max)) were higher in PH compared with control with preserved cardiac index and RV O-2 delivery. However. RV functional reserve, as measured by the exercise-induced relative change (Delta) in cardiac index, dP/dt(max), and end-systolic elastance (E-es). was decreased in PH, and RV pulmonary arterial coupling was lower both at rest and during exercise in PH. Furthermore, the increase in RV O-2 delivery was attenuated in PH during exercise principally due to a lower systolic coronary blood flow in combination with an attenuated increase in aorta pressure while arterial O-2 content was not significantly altered in PH. Moreover, RV O-2 delivery reserve correlated with RV functional reserve. Delta cardiac index (r(2) = 0.85), Delta dP/dt(max) (r(2) = 0.49), and Delta E-es (r(2) = 0.70), all P < 0.05. The inability to sufficiently increase RV O-2 supply to meet the increased O-2 demand during exercise is principally due to the reduced RV perfusion relative to healthy control values and likely contributes to impaired RV contractile function and thereby to the limited exercise capacity that is commonly observed in patients with PH. NEW & NOTEWORTHY Impaired right ventricular (RV) O-2 delivery reserve is associated with reduced RV functional reserve during exercise in a swine model of pulmonary hypertension (PH) induced by pulmonary vein banding. Our data suggest that RV function and exercise capacity might be improved by improving RV O-2 delivery.