Neuroprotective role of naringenin against methylmercury induced cognitive impairment and mitochondrial damage in a mouse model.
Environmental Toxicology and Pharmacology(2019)
Abstract
•Methylmercury (MeHg) intoxication is associated with profound neurotoxicity.•Naringenin (NAR), a polyphenol, forestalls MeHg-induced neuronal damage in Swiss albino mice.•MeHg caused oxidative stress, mitochondrial dysfunction leading to neuronal death.•NAR conditioning aided in redox homeostasis, functional mitochondria, neuronal survival.•NAR improved MeHg-mediated loss of cognition showing its neuroprotective potential.
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Key words
ANOVA,ARE,CA3,CDNB,DMSA,DMSO,DNPH,dNTPs,DTNB,GSH,GST,MDA,MeHg,MPTP,NAR,Nrf2,OXPHOS,PBS,PCR,PD,ROS,SEM
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