Dispersive Magnetic Solid Phase Extraction Coupled to Direct Analysis in Real Time Mass Spectrometry for High Throughput Analysis of Trace Environmental Contaminants.

Coupling dispersive magnetic solid-phase extraction (DMSPE) to direct analysis in real time mass spectrometry (DART-MS) with a newly developed metal iron probe enables high-throughput, sensitive detection of herbicides such as triazine in environmental waters. Magnetic graphene oxide was used as a dispersive sorbent because it increased adsorption capacity in the DMSPE process. The planar structure and excellent thermal conductivity of graphene oxide facilitated the desorption and ionization of target analytes in DART-MS analysis. The iron probe, which is designed to fit into the moving trail of the DART interface, served as the sorbent collector as well as the support for the magnetic graphene oxide after DMSPE, and was put directly into the DART system. The ratio of magnetic core to graphene oxide in the nanoparticles and other key parameters in DMSPE and DART-MS procedures were systematically investigated and optimized. In addition, the presence of water on the sorbent proves to have a significant effect on DART-MS analysis. No organic solvents are used in this method, and the reusable iron probe is of low cost. Under the optimal conditions, limits of detection were found in the range of 1.6-152.1 ng/L for the triazines. Recovery and reproducibility were found to be in the ranges of 87.5-115.0% and 1.9-10.2%, respectively, for the six herbicides studied. The analytical performance of the DMSPE-DART-MS method indicated that applications for trace analysis of other compounds in liquid samples are also possible.