Adolescent Exposure to Fluoxetine Impairs Serial Pattern Learning in the Serial Multiple Choice (SMC) Task in Adult Rats.

Jessica L Sharp,Megan E Miller-Cahill,Samantha M Renaud,Shannon M A Kundey,Brian M Kelley,Amanda Willey Matoushek,Katherine H Dyer,Claire C Jackman,Stephen B Fountain,James D Rowan

Neurobiology of Learning and Memory（2019）

Cited 7|Views3

No score

Abstract

•Rats received 1.0, 2.0, or 4.0 mg/kg/day of fluoxetine (FLX) during adolescence.•Rats were trained on a serial multiple choice (SMC) task in adulthood.•Adolescent FLX differentially impaired acquisition of serial pattern element types.•FLX impaired stimulus-response and multiple-cue learning but not rule-learning.•Adolescent exposure to FLX impaired some aspects of adult cognition in rats.

Translated text

Key words

Fluoxetine,Adolescent drug exposure,Sequential behavior,Serial pattern learning,Serial multiple-choice task,Rat

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined