Adolescent Exposure to Fluoxetine Impairs Serial Pattern Learning in the Serial Multiple Choice (SMC) Task in Adult Rats.
Neurobiology of Learning and Memory(2019)
Abstract
•Rats received 1.0, 2.0, or 4.0 mg/kg/day of fluoxetine (FLX) during adolescence.•Rats were trained on a serial multiple choice (SMC) task in adulthood.•Adolescent FLX differentially impaired acquisition of serial pattern element types.•FLX impaired stimulus-response and multiple-cue learning but not rule-learning.•Adolescent exposure to FLX impaired some aspects of adult cognition in rats.
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Key words
Fluoxetine,Adolescent drug exposure,Sequential behavior,Serial pattern learning,Serial multiple-choice task,Rat
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